Regulations/Policies about Single IRB (sIRB)
As part of the revised Common Rule and the NIH single IRB mandate, all domestic, federally funded, multi-site research studies are required to use a single IRB.
NIH Policy, effective date January 25, 2018
- This policy applies to the domestic sites of NIH-funded multi-site studies where each site will conduct the same protocol involving non-exempt human subjects research.
- It does not apply to career development, research training or fellowship awards, foreign sites, VA sites, sites involving tribal nations and noncompeting continuation awards.
Additional Resources for NIH Policy:
- Single IRB Policy for Multi-site Research Resource Page
- NIH FAQs for Single IRB Policy for Multi-site Research
Revised Common Rule Regulations, effective date January 20, 2020
- This policy applies to all domestic sites participating in a federally funded multi-site study following the Common Rule requirements
- This policy does not apply to:
- research for which any Federal department or agency supporting or conducting the research determines and documents that the use of the single IRB is not appropriate
- cooperative research for which more than single IRB review is required by law
Additional Resources for revised Common Rule in relation to sIRB:
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